Creating New Knowledge With an Interdisciplinary Approach.
The work produced by Dr. Christopher Percival is unique and diverse in its approach. As an Assistant Professor at Stony Brook University, Dr. Percival has dedicated his career to unraveling the mysteries of craniofacial variation. Blending morphometric quantification, genetic analysis, and an understanding of tissue-level developmental biology, he hopes to gain a deeper understanding of the form and function of the skull throughout development and evolutionary history, but his journey has been driven by a desire to understand the complex systems that produce evolutionary variation and an ability to include an interdisciplinary perspective to his work.
Form and Function: A Journey Through Craniofacial Variation
Dr. Percival's overarching research goal is both elegant and ambitious: to understand the complex systems that form the genetic and developmental basis for variation in skull morphology. He delves into the very core of our existence, exploring how our craniofacial features come into being and why they differ from person to person, and species to species.
At the heart of his research lies the use of mouse models, which serve as invaluable tools for generating large samples with known genotypes within controlled environments. This allows Dr. Percival to quantify the genetics of normal variation in craniofacial structures, offering a glimpse into the intricate dance between genes and form. By manipulating gene expression patterns during early head development in these models, he can pinpoint the changes in craniofacial form associated with specific mutations, shedding light on the etiology of craniofacial defects.
But Dr. Percival's work doesn't stop with the mice. He has a keen eye for understanding the broader implications of his findings. Because many fundamental developmental processes are shared between humans, primates, and mice, his research illuminates potential bases for morphological and functional variation within populations, between primate species, and across recent human ancestors. It's a holistic approach to understanding the form and function of our craniofacial features, one that bridges the gaps between species and time, bringing us closer to understanding the essence of our humanity.
Bridging the Gap: Integrating Genetics, Development, and Morphology
All of Christopher Percival’s work is from an anatomical perspective, he remarked “If you ask someone at the Society for Developmental Biology if I’m a developmental biologist they might init say no…because I don’t do the types of experiments that they’d typically do. I found it really fulfilling to collaborate with people that do more traditional developmental biology…coming from an anatomical perspective…meeting in the middle.” With this perspective, Percival’s work blends the traditional approach from different fields: genetics, development, and morphology to produce new knowledge and gain a deeper understanding. He recognizes that a comprehensive understanding of craniofacial variation requires the integration of these three levels of analysis. By combining genetic insights, cellular-level investigations, and detailed morphological studies, he strives to create a more complete picture of craniofacial development.
Through his collaborative efforts, Dr. Percival has pushed the boundaries of craniofacial research. He has forged partnerships with experts from diverse fields, fostering an interdisciplinary approach that promises to unlock new insights into the form and function of our craniofacial features. His collaborative approach and commitment to gaining a deeper understanding was recognized at the 2023 Anatomy Connected meeting in Washington D.C., where he was honored with the Early Career Anatomist Publication award.
Development from an Anthropology Perspective
An interest in anthropology and evolutionary biology began Christopher on his journey of scientific inquiry. He is now returning to these roots, using anthropology to inform future work, taking the knowledge gained from his biomedical research and bringing it back into an evolutionary context.
Building onto the traditional mouse model, Percival is now taking a comparative approach to deepen his understanding of how genetic expression manifests across species and throughout our evolutionary past. For Dr. Percival, craniofacial research isn't just about understanding biology; it's about viewing it through the lens of anthropology. He recognizes that the study of craniofacial variation is intrinsically linked to our understanding of human evolution, diversity, and identity. It's about how we define ourselves as a species and how our craniofacial features have evolved over time.
In his own words, "I am interested in understanding how morphology occurs. How do you produce the variation we see? How does the anatomy become the way it is?" This curiosity drives his research, propelling him to explore the intricate tapestry of craniofacial development from an anthropological perspective.
On the path to deciphering the enigma of craniofacial form and function, Dr. Christopher Percival is combining experience with interdisciplinary relationships to create a unique perspective that may lead to a deeper understanding of the complexity and variability that forms the very essence of our humanity.
To keep up with the Dr. Percival’s work, check out his website and be sure to follow Stony Brook University’s Anthropology Graduate Program on Twitter @IDPAS_SBU