Funding Opportunities

Recently announced Requests for Proposals (RFPs), Requests for Applications (RFAs), and other funding opportunities of possible interest to AAA members are listed below by date of posting and remain on the list through the closing date. To search this page for a particular topic, press Ctrl-F, then enter the keyword for which you are searching.

Check AAA’s AnatomyLink (www.anatomy.org) for regular updates on research grants, fellowships, and other funding opportunities. Just go to “Awards/Grants” and click on “RFPs/RFAs.”

Posted 04/29/08

Tumor Stem Cells in Cancer Biology, Prevention, and Therapy (P01)
To stimulate research on tumor stem cell biology, including the identification and characterization of specific genetic and functional signatures (e.g., biomarkers) of tumor stem cells. The overall goal is the translation of basic research findings into clinical practice in the contexts of both hematological and solid tumor malignancies.  Letters of intent due June 10; applications due July 10.

Genetic Screens to Enhance Zebrafish Research (R01)
Investigator-initiated applications to exploit the power of the zebrafish as a vertebrate model for biomedical and behavioral research.  Applications proposing to develop new genetic screens of high priority to the zebrafish community that will advance the detection and characterization of genes, pathways, and phenotypes of interest in development and aging, organ formation, neural processes, behavior, sensory processes, physiological processes, and disease processes are welcome.  Letters of intent due August 25, 2008, 2009, 2010; applications due September 24, 2008, 2009, 2010.

Enhancing Zebrafish Research with Research Tools and Techniques (R01)
Investigator-initiated applications to exploit the power of the zebrafish as a vertebrate model for biomedical and behavioral research. Applications proposing to develop new research tools or techniques that are of high priority to the zebrafish community and that will advance the detection and characterization of genes, pathways, and phenotypes of interest in development and aging, organ formation, neural processes, behavior, sensory processing, physiological processes, and disease processes are welcome. Letters of intent due August 17, 2008, 2009, 2010; applications due September 17, 2008, 2009, 2010.

Posted 03/11/08

HHMI Early Career Scientist Competition
The Howard Hughes Medical Institute (HHMI) has announced a new program aimed at researchers who have run their own labs for two to six years and are now at a critical point in establishing their own vibrant, independent research programs.  Through a national competition that opens on March 10, HHMI plans to select as many as 70 early career scientists from a wide range of scientific disciplines relevant to biological and medical inquiry. These scientists, most of whom will be assistant professors at the time of the award, will receive six-year, non-renewable appointments to HHMI and receive the substantial research support necessary to move their research in creative, new directions. HHMI will invest more than $300 million in this first group of scientists and plans a second competition in 2011.  Applications will be accepted between May 1, 2008, and June 10, 2008, at 2 p.m. ET

Molecular Phenotypes for Lung Diseases (R01)
NHLBI award to stimulate research that will define or subcategorize human lung diseases at a molecular level enabling early diagnosis, prognosis, and personalized treatment of these diseases.  The measurement of whole-genome gene expression at the RNA level will be the primary approach to systematically collect molecular phenotyping data for common and rare lung diseases. Letters of intent due April 5; applications due May 5.

Small Grants for Lung Tissue Research (R03)
To promote tissue-based research on COPD (chronic obstructive pulmonary disease) and interstitial fibrotic lung conditions, including studies to establish proof-of-concept in humans for novel mechanisms of pathogenesis. Research must use lung biospecimens and data collected by the Lung Tissue Research Consortium (LTRC).  Letters of intent due April 8 & Sept. 22; applications due May 9 & Oct. 17.

Functional Links between the Immune System, Brain Function and Behavior (R01)
Multi-Institute support to study neuroimmune molecules and mechanisms involved in regulating normal and pathological functions of the central nervous system (CNS).  Standard receipt dates.

Posted 02/26/08

Posted 02/06/08

NIH Director’s New Innovator Award
To support a small number of new investigators of exceptional creativity who propose bold and highly innovative new research approaches with the potential to produce a major impact on broad, important problems in biomedical and behavioral research. Applications due March 31. 

Shared Instrumentation Grant Program (S10)
To purchase or upgrade commercially available instruments that cost at least $100,000; maximum award is $500,000. Types of instruments supported include confocal and electron microscopes, biomedical imagers, mass spectrometers, DNA sequencers, biosensors, cell sorters, X-ray diffraction systems, and NMR spectrometers among others. Applications due: March 24.  

Notice Regarding Authentication of Cultured Cell Lines
NIH believes tmisidentification of cell cultures is a serious problem.  However, because authentication methods can be quite specific and are continuously evolving, it would be impractical for NIH to require application of particular methods in all grant applications.  The peer review process has been designed to carefully examine the experimental approach and assure that the investigators propose appropriate methods and resources for the described study.  Grant applications that fail to employ such practices would not be considered of the highest quality and such manuscripts would not fare well in the journal review process. 

NIH Reduces Temporary “Error Correction Window” for Electronic Grant Applications from Five Business Days to Two
NIH has reduced the “error correction window” (i.e. , the time allowed after the submission deadline to address NIH system identified errors/warnings) from five (5) business days to two (2) business days for all electronically submitted grant applications with submission deadlines on or after January 8.  

Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Predoctoral Training Program in Systems Biology of Developmental Biology & Birth Defects (T32)
Letters of intent due April 25, 2008, 2009 and 2010; applications due May 25, 2008, 2009 and 2010.

Innovative Technologies for Molecular Analysis of Cancer (R21)
Exploratory research projects focused on the inception and early stage development of highly innovative cancer-relevant technologies with emphasis on technically innovative molecular analysis tools with the potential to add a new quality to the investigations of the molecular basis of cancer in vitro, in situ, and/or in vivo.  Letters of intent due: April 29, August 24; application due: May 29, September 24. 

NIH Administrative Revisions for Human Pluripotent Stem Cell (hPSC) Research Using Non-Embryonic Sources
One-year administrative revisions for NIH-funded grantees to encourage research into the derivation and/or characterization of human pluripotent stem cells (hPSCs) from non-embryonic sources.  Applications due April 1.

Thyroid in Aging (R01)
To promote basic, translational, and clinical studies leading to increased understanding of the physiology of the aging thyroid and improved diagnosis and management of thyroid disease in older adults. 

Nanoscience and Nanotechnology in Biology and Medicine (R01)
Nanotechnology and nanoscience have the capacity to drive a new wave of medical innovation through the engineering of bioactive nanoscale structures, processes, and systems based on the advancement of our understanding of biology at the nanoscale. Nanoscience and nanotechnology refer to research and development on the understanding and control of matter at a length scale of approximately 1 - 100 nanometers, where novel properties and functions occur because of the size.  

NCI Transition Career Development Award to Promote Diversity (K22)
Primarily for those with clinical doctoral degrees as well as those with doctoral degrees working in the areas of cancer prevention, control, behavioral, or population science research, from the mentored stage of career development in academic cancer research to the independent stage.

Posted 01/09/08

Short Courses in Integrative and Organ Systems Pharmacology (R25)
Development and delivery of short courses (2-3 weeks intensive training) to introduce students to the knowledge and skills needed for studies of integrative organ system and whole organism biological responses to drugs and other physiological perturbations
Letters of intent due January 26; applications due February 26.

Nanoscience and Nanotechnology in Biology and Medicine (R01)
A major challenge facing medicine is to develop novel and more sophisticated approaches for the diagnosis, treatment and management of an array of diseases and traumatic injuries. Nanotechnology and nanoscience have the capacity to drive a new wave of medical innovation through the engineering of bioactive nanoscale structures, processes, and systems based on the advancement of our understanding of biology at the nanoscale. Nanoscience and nanotechnology refer to research and development on the understanding and control of matter at a length scale of approximately 1 - 100 nanometers, where novel properties and functions occur because of the size.

Nanoscience and Nanotechnology in Biology and Medicine (R21)
See details above.

NCI Transition Career Development Award to Promote Diversity (K22)
To facilitate the transition of investigators from minority groups underrepresented in biomedical research, primarily those with clinical doctoral degrees as well as those with doctoral degrees working in the areas of cancer prevention, control, behavioral, or population science research, from the mentored stage of career development in academic cancer research to the independent stage.

Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Predoctoral Training Program in Systems Biology of Developmental Biology & Birth Defects (T32)
National Institute of Child Health and Human Development (NICHD)

Posted 12/18/07

NIH Director’s New Innovator Award
To support a small number of new investigators of exceptional creativity who propose bold and highly innovative new research approaches that have the potential to produce a major impact on broad, important problems in biomedical and behavioral research. Opening Date: March 3, 2008.

NIH Director’s Pioneer Award
To fund  highly innovative approaches that have the potential to produce an unusually high impact in a broad area of biomedical and behavioral research. This is a grant for conducting research, rather than a reward for past achievements. Applications due: January 16, 2008

Short Term Courses in Developmental Epigenetics (T15)
For development and conduct of short-term continuing education programs in cutting edge techniques and applications of epigenetics to include both didactic and hands-on laboratory experiences. Letters of intent due February 18, 2008; applications due March 18, 2008.

Human Pluripotent Stem Cell (hPSC) Research Using Non-Embryonic Sources (R01)
Agency-wide announcement to encourage new research applications proposing research on hPSCs from non-embryonic sources. Opening date: January 5, 2008.

Human Pluripotent Stem Cell (hPSC) Research Using Non-Embryonic Sources (R21)
See above.  Opening date: January 16, 2008.

Thyroid in Aging (R01)
To promote basic, translational, and clinical studies leading to increased understanding of the physiology of the aging thyroid and improved diagnosis and management of thyroid disease in older adults. Opening date:  January 5, 2008

Thyroid in Aging (R21) (R03)
See above. Opening date: January 16, 2008.

Shared Instrumentation Grant Program (S10)
To purchase or upgrade commercially available instruments that cost at least $100,000. The maximum award is $500,000. Types of instruments supported include confocal and electron microscopes, biomedical imagers, mass spectrometers, DNA sequencers, biosensors, cell sorters, X-ray diffraction systems, and NMR spectrometers among others. Applications due: March 24, 2008.

Posted 12/03/07

Notice Regarding Authentication of Cultured Cell Lines
Based on recent information, NIH believes that misidentification of cell cultures is a serious problem. However, because authentication methods can be quite specific and are continuously evolving, it would be impractical for NIH to require application of particular methods in all grant applications.  The peer review process has been designed to carefully examine the experimental approach and assure that the investigators propose appropriate methods and resources for the described study. Grant applications that fail to employ such practices would not be considered of the highest quality and such manuscripts would not fare well in the journal review process.

NIH Reduces Temporary “Error Correction Window” for Electronic Grant Applications from Five Business Days to Two
NIH will reduce the “error correction window” (i.e. the time allowed after the submission deadline to address NIH system identified errors/warnings) from five (5) business days to two (2) business days for all electronically submitted grant applications with submission deadlines on or after January 8, 2008.

Posted 10/30/07

Angiogenesis in the Nervous System in Health and Disease (R01)
NINDS, NEI, NIA, NCI, and NIDDK encourage proposals on the study of the mechanisms controlling angiogenic responses to physiological and pathological stimuli, the development and patterning of nervous system vasculature, and the etiology of disorders affecting development and/or ongoing angiogenesis in nervous system vasculature. Opening Date:   January 5, 2008 ; standard receipt dates.

Angiogenesis in the Nervous System in Health and Disease (R21)
Similar to above. Opening Date: January 16, 2008; standard receipt dates.

Monoclonal Antibodies for Developmental Neuroscience - Request for Targets (NIH Neuroscience Blueprint)
The NIH Neuroscience Blueprint Neurodevelopment Initiative is now accepting suggestions for the generation of monoclonal antibodies against crucial neurodevelopmental targets.  Please provide a scientific justification of the biological relevance of the target molecule, the importance of the proposed antibodies to the neurodevelopment research community, and the availability and suitability of existing polyclonal and/or monoclonal antibodies. 
Responses due by September 30, 2008.

Prefrontal Cortical Influences on Brain Systems Supporting Complex Mental Function (R01)
Proposals to use novel electrophysiological, molecular, genetic and/or imaging techniques in animals to examine the fundamental mechanisms by which regions in the mature and developing prefrontal cortex interact with other cortical and subcortical systems to give rise to sophisticated behavior and complex mental function (e.g., cognition, emotion, reward, motivation). Letters of intent due December 11; applications due January 11, 2008.

Prefrontal Cortical Influences on Brain Systems Supporting Complex Mental Function (R21)
Similar to above. Applications due January 11, 2008.

Genetic Susceptibility & Variability of Human Structural Birth Defects (R01)
NICHD, NIDCR, and NIEHS encourage innovative investigator-initiated applications designed to study fundamental developmental processes using animal models in conjunction with translational/clinical approaches with the goal of advancing our understanding of the etiology of structural birth defects . Opening Date: January 5, 2008 ; standard receipt dates.

Posted 10/1/07

Development of High Resolution Probes for Cellular Imaging (R01)
NIGMS and NHGRI invite applications to support multi-investigator teams to develop new technologies to enable high sensitivity molecular detection in living cells. This funding opportunity is to encourage and facilitate novel, high-risk strategies to create fundamentally new probes with enhanced spectral characteristics with the goal of improving detection schemes by a factor of 10 to 100. Parallel improvements in probe targeting, cellular delivery, and signal detection are also encouraged. The ultimate goal will be to develop probes and delivery strategies that can be used routinely to achieve single molecule sensitivity for imaging dynamic processes within living cells. Letters of Intent due December 14, 2007; applications due January 14, 2008 via Grants.gov no later than 5:00 p.m. local time (of the applicant institution/organization).

Posted 8/7/07

NIH Request for Information (RFI): Creating a Gene Expression Atlas for Developing Rhesus Macaque Brain (Neuroscience Blueprint)
As part of the planning process for Blueprint activities related to neurodevelopment, participating NIH Institutes and Centers request responses to questions related to the hippocampus, the primary visual cortex, and the medial prefrontal cortex.

Lymphatic Biology in Health and Disease (R01)
To stimulate research on the biology of the lymphatic system at all biologic levels: molecular, cellular, tissue, organ, and whole body levels, as well as research on innovations for identifying and intervening in lymphatic diseases across all age groups and disease states. Applications due: September 28, 2007, September 18, 2008, September 18, 2009.

Developmental Mechanisms of Human Structural Birth Defects (P01)
To support innovative, multidisciplinary, interactive, and synergistic program projects that integrate basic, translational, and clinical approaches to understanding the developmental biology and genetic basis of congenital human malformations. Expiration Date: May 26, 2010

NIDCR Small Grant Program for New Investigators (R03)
For scientists in the early stages of establishing an independent research career in dental and craniofacial research. Preliminary data are not required.

Bridges to the Doctorate Program (R25)
Promotes inter-institutional partnerships to improve the quality and quantity of students from underrepresented groups and or health disparities populations being trained as the next generation of biomedical and behavioral research scientists. Applications due : Sept.18, 2007; Jan. 18, 2008; Sept. 18, 2008; Jan.20, 2009; Sept. 18, 2009; Jan. 20, 2010.

Bridges to the Baccalaureate Program (R25)
Promotes inter-institutional partnerships to improve the quality and quantity of students from underrepresented groups and or health disparities populations being trained as the next generation of biomedical and behavioral research scientists. Applications due : Sept.18, 2007; Jan. 18, 2008; Sept. 18, 2008; Jan.20, 2009; Sept. 18, 2009; Jan. 20, 2010.

Posted 7/25/07

Request for Information (RFI): NIH System to Support Biomedical and Behavioral Research and Peer Review
NIH is seeking comments regarding its support of biomedical and behavioral research, including peer review, with the goal of examining the current system to optimize its efficiency and effectiveness. NIH is especially interested in creative suggestions, even if they involve radical changes to the current approach.

Posted 7/24/07

EUREKA (Exceptional, Unconventional Research Enabling Knowledge Acceleration)
The National Institutes of Health announces a new program to fund exceptionally innovative research that, if successful, will have an unusually high impact. The program includes direct costs of up to $800,000 over 4 years and a specialized R01 application focusing on significance and innovation. NIGMS anticipates making between 13-17 awards under this program in Fiscal Year 2008; NINDS, NIDA & NIAID plan to fund additional awards. Applications due October 24, 2007.

NIA Mutant Mouse Aging Colony for Biogerontology Research
The National Institute on Aging announces the development of an aging colony of mutant and engineered mouse models of interest to the aging research community. Tthe colony consists of four lines: Snell Dwarf mice, Ames Dwarf mice, a GFP reporter transgenic line, and the mutant alpha-synuclein transgenic line B6; C3H-Tg (Prnp-SNCA) M83/Vle. The colony was recently initiated so availability is limited. The goal of this colony is to provide small numbers of mice at different ages to facilitate NIH-funded studies on aging. Information on the mouse models, selected references, and ordering procedures and forms are available on the website above.

Posted 5/21/07

Development of Animal Models and Related Biological Materials For Research (R21)
Solicits Exploratory/Developmental grant applications from applicant organizations proposing to develop, characterize or improve animal models for human disease or to improve diagnosis and control diseases of laboratory animals that may interfere with research. The total project period for an application submitted in response to this funding opportunity may not exceed two years. Direct costs are limited to $275,000 over an R21 two-year period, with no more than $200,000 in direct costs allowed in any single year. The R21 is not renewable.

Collaborative Studies on Systems Biology of Complex Phenotypes (R01)
NIGMS invites applications for collaborative research projects that use systems biology approaches to investigate the mechanisms that underlie genetic determination of complex phenotypes. These projects will combine computational modeling approaches and experimental validation of predictive models. It is expected that a team of at least two principal investigators (PIs), one with expertise in systems biology and the other with expertise in the genetics of humans or model organisms, will apply for funding under this FOA. Applications from a single investigator or that propose solely data production and accumulation will be considered non-responsive and will not be reviewed. Application due: October 23, 2007.

Posted 4/6/07

Centers for Neurodegeneration Science (CNS) (P01)
NIEHS and NIA invites applications for Centers for Neurodegeneration Science (CNS) to conduct an integrated program of research that combines human studies with basic mechanistic research in relevant model systems to understand how environmental factors contribute to the etiology, progression, phenotypic expression, treatment and/or prevention of neurodegenerative diseases. Letters of intent due June 24; applications due July 24.

Posted 3/19/07

Administrative Supplements for Making Knockout Mice
The goal of this program is to support use of existing resources and to ensure that ES cell lines are converted into frozen embryos that are available from a repository. Submission deadline: May 1, 2007.

NINDS Institutional Center Core Grants to Support Neuroscience Research (P30)
NINDS will resume accepting applications under PAR-05-070 beginning with the May 25, 2007 receipt date. When evaluating the leadership and administration of a proposed Center Core, reviewers will consider the ability of the Center to provide opportunities for new investigators to develop data that support applications for independent research funding. 

A Systems Approach to Salivary Gland Biology (R01)
To stimulate innovative research in the application of a systems biology approach to inform as well as predict salivary gland function, dysfunction and response to treatment of salivary gland disorders. Letters of intent due Oct. 15; applications due Nov. 14.

NIDCR Mentored Quantitative Research Development Award in A Systems Approach to Salivary Gland Biology (K25)
To stimulate innovative research by investigators whose quantitative science and engineering research has thus far not been focused primarily on questions of health and disease. Research focus would be on the application of a systems biology approach to inform as well as predict salivary gland function, dysfunction and response to treatment of salivary gland disorders. Letters of intent due Oct. 15; applications due Nov. 15.

Dental School Joint DDS or DMD/Masters Degree NRSA Research Training Program (T32)
To make research training an integral component of the dental school environment and encourage more dental students to pursue academic research careers by providing an opportunity to gain research experience. Letters of intent due Aug. 25, 2007, 2008, 2009; applications due Aug. 25, 2007, 2008, 2009.

Posted 3/2/07

Innovative Technologies for Molecular Analysis of Cancer (R21) (R33)
Exploratory research projects focused on the development of highly innovative cancer-relevant molecular biology technologies. Technology encompasses methods and tools that enable research, including, but not limited to, instrumentation, techniques, and devices. Letters of intent due April 29 & August 27; a pplications due May 29 and September 27.

Posted 1/12/07

Stem Cells and Cancer (R01)
To stimulate research on all aspects of stem cell biology, including research into the molecular and biochemical regulation of embryonic and adult stem cell behavior. We anticipate that the results of such research will ultimately improve the specificity and long-term effectiveness of cancer therapy, through the targeting of those cells most responsible for disease progression and metastasis.

Characterization, Behavior and Plasticity of Pluripotent Stem Cells (R01)
Several NIH institutes invite applications for studies on the characterization, behavior, and plasticity of human and non-human stem cells, regulation of their replication, differentiation, integration and function in the nervous system, and the identification and characterization of normal and tumor stem cells.

Proteomics in Auditory Developmental and Disease Processes (R01)
High throughput technologies with the singular goal of acquiring the most inclusive collection of representative genomic sequence, transcript, and/or protein, is the current view of biomedical research. Data sets of transcript and protein expression provide investigators a comprehensive cellular snapshot of existing proteins of a given protein complex, cell type, tissue and environmental condition. While both sequence and transcript profiling have made significant advances in their technologies and utilization, there remains a need to comprehensively catalog protein content within many important cell types and tissues of the auditory sensory system.

Networks and Pathways Collaborative Research Projects (R01)
For research project grants that will leverage and complement the ongoing technology development being pursued in the National Technology Centers for Networks and Pathways (TCNPs), a program of the NIH Roadmap for Medical Research. These collaborative projects should focus either on addressing a challenging biological problem using the technology developed in one or more of the TCNPs, or on the development of technology that will complement that which is being developed in the centers.

Interactions Between Stem and Progenitor Cells and the Microenvironment in Vivo (R01)
For studies on the cellular and molecular signaling between the local environment within organisms and stem and progenitor cells that are either introduced as transplants or are normally resident within host tissues and organs. The objective of this initiative is to promote a thorough exploration and characterization of the bi-directional communication between multipotent cells and the three-dimensional local milieu or niche that they encounter in vivo under normal and compromised states, such as with aging or following injury, disease or drug exposure.

Neurovascular Mechanisms of Brain Function and Disease (R01)
NINDS invites applications for studying the integration of neurobiological and cerebrovascular mechanisms in the adult, aged and pediatric brain in health and disease.

The Role of Nuclear Receptors in Tissue and Organismal Aging (R01)
For research into underlying biologic mechanisms involving nuclear receptors, their co-regulators and intracellular signaling systems in the process of aging and the connections of the aging process with pathophysiology in middle- and old-age.

Posted 12/18/06

2007 NIH Director's Pioneer Award Program (DP1)
A High-Risk Research initiative of Research Teams of the Future. The term “pioneering” is used to describe highly innovative approaches that have the potential to produce an unusually high impact and the term “award” is used to mean a grant for conducting research, rather than a reward for past achievements. Applications due Jan. 16, 2007.

Tools for Zebrafish Research (R01)
T o exploit the power of the zebrafish as a vertebrate model for biomedical and behavior research. Applications are welcome proposing to develop new tools or genetic or genomic resources of high priority to the zebrafish community that will advance the detection and characterization of genes, pathways, and phenotypes of interest in development and aging, organ formation, behavior, sensory processing, physiological processes, and disease processes. Letters of intent due Aug. 19, 2007; applications due Sept. 19, 2007.

Basic Research in the Bladder and Lower Urinary Tract (R01)
F or research studies that focus on basic cellular, molecular, genetic, and developmental mechanisms of the normal and abnormal function of the bladder and lower urinary tract. An important goal is to attract new and established investigators from a variety of basic science research areas to apply their knowledge, skills, and tools to studies of the bladder and lower urinary tract. Opening date: Jan. 5, 2007.

Developmental Biology and Regeneration of the Liver (R01)
T o invite qualified scientific investigators to submit applications on liver development and regeneration to fully define the molecular and cellular mechanisms underlying these processes in health and disease and to apply these findings to developing improved therapies for liver disease. Opening date: Jan. 2, 2007.

Structural Analyses of the Ligand-Binding Properties of Taste and Smell Receptors (R01)
T o foster innovative collaborative research to characterize the structural properties of taste and smell receptors. Additional emphasis is placed on the characterization of the interactions among odors, pheromones, and taste substances with their cognate receptors, and the identity of the critical ligand-receptor binding sites that determine sensitivity and selectivity. Opening date: Jan. 5, 2007.

Cell Lineage and Developmental Studies in Hearing and Balance (R01)
T o expand developmental research in the auditory and vestibular sensory systems via cellular and molecular approaches applied to developmental events important for hearing and balance sensory function. Opening date:  Jan. 5, 2007

Request for Information (RFI): Tools and Resources for Human Embryonic Stem Cell Research in the Nervous System (Neuroscience Blueprint)
This is a time-sensitive RFI to determine how best to accelerate research directed toward targeted differentiation of human embryonic stem cells (hESCs) into specific neuronal and glial cell types.  Responses should be pertinent to the interests of one or more of the NIH Neuroscience Blueprint Institutes and Centers (ICs) and should be focused on application of hESC biology to specific issues involving the unique features of the nervous system.

Ruth L. Kirschstein National Research Service Awards (NRSA) for Individual Postdoctoral Fellows (F32)
NIH awards individual postdoctoral research training fellowships to promising applicants with the potential to become productive, independent investigators in research fields relevant to the missions of participating NIH Institutes and Centers.

Research on Sleep and Sleep Disorders (R01)
T o advance biomedical knowledge related to sleep or sleep disorders, improve understanding of the neurobiology or functions of sleep over the life-span, enhance timely diagnosis and effective treatment for individuals affected by sleep-related disorders, or implement and evaluate innovative community-based public health education and intervention programs. Opening date: Jan. 5, 2007.

Animal Models of NIDDK Relevant Diseases (R01)
To provide support for the development and validation of new animal models of NIDDK-relevant diseases where animal models are either inadequate or lacking. New and/or improved animal models should be designed to facilitate preclinical testing of diagnostic, preventive or therapeutic interventions. Opening date: Jan. 5, 2007.

Posted 10/11/06
NIH announces shift in grant submission dates to faciliate electronic submission.

Posted 9/25/06
Knockout Mouse Project (KOMP) Repository (U42)
The goal of the NIH-funded Knockout Mouse Project (KOMP) is to generate a comprehensive resource of null mutant alleles, with a reporter, using gene targeting mutagenesis in mouse strain C57BL/6. The purpose of this Funding Opportunity Announcement (FOA) is to establish a resource repository to collect and archive the null mutant alleles, primarily in the form of cryo-preserved embryonic stem (ES) cells, as well as associated DNA constructs, and cryo-preserved embryos or live mice created by the KOMP. The successful KOMP repository should aim to become self supporting over time. Letter of intent due October 30; application due November 30.

Posted 8/8/06
Development of Nonmammalian Models and Related Biological Materials For Research (R21)
Exploratory/Developmental grant applications from applicant organizations proposing to develop new non-mammalian research model systems or expand on the usefulness of existing non-mammalian model systems. Examples of types of model system that will be considered include fish and other lower vertebrates, invertebrates, microorganisms and cell and tissue culture systems. Models to be considered must be applicable to the research interests of two or more categorical NIH Institutes/Centers. Standard application dates. 

Posted 7/17/06
The Role of Nuclear Receptors in Tissue and Organismal Aging (R01)
To stimulate research into underlying biologic mechanisms involving nuclear receptors, their co-regulators and intracellular signaling systems in the process of aging and the connections of the aging process with pathophysiology in middle- and old-age. R21 runs parallel. Standard application dates.

Posted 7/5/06
Bioengineering Research Partnerships (BRP) [R01]
To support BRPs for basic, applied, and translational multi-disciplinary research that addresses important biological or medical research problems and that applies an integrative, systems approach to develop knowledge and/or methods to prevent, detect, diagnose, or treat disease or to understand health and behavior. The partnership must include appropriate bioengineering or allied quantitative sciences in combination with biomedical and/or clinical components. Applications due September 20, 2006 and January 22, 2007.

The Role of Nuclear Receptors in Tissue and Organismal Aging (R01)
To stimulate research into underlying biologic mechanisms involving nuclear receptors, their co-regulators, and intracellular signaling systems in the process of aging and the connections of the aging process with pathophysiology in middle- and old-age. Standard application dates.

Posted 6/28/06
The Role of Nuclear Receptors in Tissue and Organismal Aging (R01)
To stimulate research into underlying biologic mechanisms involving nuclear receptors, their co-regulators, and intracellular signaling systems in the process of aging and the connections of the aging process with pathophysiology in middle- and old-age. Standard application dates.

Bioengineering Research Partnerships (BRP) [R01]
To support BRPs for basic, applied, and translational multi-disciplinary research that addresses important biological or medical research problems and that applies an integrative, systems approach to develop knowledge and/or methods to prevent, detect, diagnose, or treat disease or to understand health and behavior. The partnership must include appropriate bioengineering or allied quantitative sciences in combination with biomedical and/or clinical components. Applications due September 20, 2006 and January 22, 2007.

Postdoctoral Training in Research on Aging in Canada (F32)
Offers postdoctoral training in research on aging at designated Canadian research institutions to encourage collaboration between the United States and Canada in identifying and developing postdoctoral-level investigators for careers in research on aging and health. Postdoctoral investigators, with a demonstrable commitment to research on aging and health, who are American citizens or legal resident aliens and who are eligible for travel to and residency in Canada may apply. Standard application dates.

Posted 6/19/06
NHLBI Exploratory Program in Systems Biology (R33)
For collaborative research projects to initiate high-risk, high impact research by multidisciplinary teams of investigators. These projects will combine computational modeling and simulation approaches with experimental validation of model predictions to advance understanding the normal physiology and perturbations associated with heart, lung, blood, and sleep (HLBS) disorders. Letters of intent due August 24, 2006 & 2007; applications due September 25, 2006 & 2007.

Joint Degeneration: Mouse Models (R21)
NIAMS, NIA, and NIDCR solicit proposals of research employing genetically defined and genetically modified mouse models to explore the biological mechanisms underlying non-inflammatory joint degeneration, or osteoarthritis. Runs in parallel with an R01 grant.

Posted 6/14/06
New Technologies for Liver Disease STTR (R41/R42)
To develop resources, research tools, instrumentations, biomarkers, devices, drugs or new and innovative approaches to diagnosis, monitoring, management, treatment and prevention of liver diseases. Areas of interest include development of reliable and practical means of diagnosis of liver diseases; biomarkers for disease activity and stage; noninvasive tests for inflammation, fibrosis and fat in the liver; and drugs, complementary and alternative modalities, biologics or molecular reagents for the therapy or prevention of liver diseases Runs in parallel with SBIR (R43/R44).

Novel Technologies For In Vivo Imaging (R21/R33)
Development and delivery of novel image acquisition or enhancement technologies and methods for biomedical imaging and image-guided interventions and therapy, which may incorporate limited pilot or clinical feasibility evaluations using either pre-clinical models or clinical studies.

Directed Stem Cell Differentiation for Cell-Based Therapies for Heart, Lung, and Blood, and Aging Diseases (R21)
To define the factors and mechanisms controlling the differentiation of embryonic or adult stem or progenitor cells, either in vitro or in vivo and stimulate new scientific advances in stem cell differentiation, including technology research that may not be hypothesis driven. The long range goal of this program is the development of methods to direct the differentiation or development of stem cells along specific cell lineages to yield replacement cells for clinical use, whether the replacement cells are formed in vitro for delivery or formed in vivo in the tissue or organ environment.

In Vivo Cellular and Molecular Imaging Centers (ICMICs)[P50]
Seeking applications for new or competing Research Center Grants. Applications due August 16, 2006 & 2007

Posted 6/7/06
Request for Information (RFI): Tools and Resources for Research in Neurodevelopment (Neuroscience Blueprint)
The NIH Blueprint goal for fiscal year 2008 is to generate novel research tools and resources to rapidly advance the field of neural development. The Blueprint represents a unique means to enhance cooperative activities among the 15 NIH Institutes and Centers that support research on the nervous system. To that end, the Blueprint encourages visionary ideas that will dramatically stimulate the field developmental neuroscience. Please send responses to BlueprintNeurodev@mail.nih.gov no later than June 21, 2006.

Posted 4/20/06
Collaborative Research in Stem Cell Biology (R21)
To foster cooperation between investigators within the U.S. and abroad with complementary expertise to develop research projects to understand how fate choices are made by stem and precursor cells in the nervous system, and to design, refine, and improve upon the use of stem cells for diagnostic or therapeutic applications to neurological disorders.  

Molecular Probes for Microscopy of Cells (R01)
To evaluate promising but unproven enabling technologies for the routine detection by microscopy of single molecules and single molecular events inside cells.  Applications are invited for (1) feasibility studies for new classes of high-signal output molecular imaging probes; (2) evaluation of general purpose methods for the delivery and specific targeting of externally administered imaging probes without disturbing cellular physiology; and (3) basic research on underlying fundamental photophysical phenomena relevant to improving the spectral properties of fluorescent probes. Letter of Intent due April 25 & July 29; applications due May 25 & August 29.

Imaging - Science Track Award for Research Transition (I/START) [R03]
T o facilitate the entry of investigators to the area of neuroimaging, including both new investigators and established investigators seeking to adopt neuroimaging methodologies in their research programs.

New Systems Biology Centers
Two new multidisciplinary centers at the Institute for Systems Biology in Seattle and the Jackson Laboratory in Bar Harbor , Maine ,will integrate experimental and computational approaches into research, technology development, and outreach programs. 

Program Projects for Basic Research on Human Embryonic Stem Cells (P01)
Supports research on the basic biology of human embryonic stem cells (hESC) and promotes the use of hESC as a model system to address significant questions in the basic biomedical sciences. Letters of intent due September 6; applications due October 6.

Posted 3/27/06
Basic Research in the Bladder and Lower Urinary Tract (R01)
Basic cellular, molecular, genetic and developmental mechanisms of the normal and abnormal function of the bladder and lower urinary tract. Runs in parallel with R21.

Testing Stem Cell Therapy in Mouse Models of Premature Aging (R01)
Runs in parallel with R21.

Developmental Biology and Regeneration of the Liver (R01)
Research on liver development and regeneration to fully define the molecular and cellular mechanisms underlying these processes in health and disease and to apply these findings to developing improved therapies for liver disease. Runs in parallel with R21.

International Neuroscience Fellowship (F05)
Unique opportunity for qualified foreign neuroscientists, at junior or mid-career level, to receive one to two years of research training in the U.S. . Letters of Intent Receipt Dates:  July 14, 2006, 2007, 2008; Application Receipt Dates:  August 14, 2006, 2007, 2008

Neurovascular Mechanisms of Brain Function and Disease (R01)
Integration of neurobiological and cerebrovascular mechanisms in the adult, aged, and pediatric brain in health and disease. This PAS encourages studies focused on improving our understanding of the dynamic interactions within the neurovascular unit (NVU), a construct consisting of brain microvascular endothelium, glia, neurons and the extracellular matrix that maintains spatial relations among them. Runs in parallel with R21.

Interactions Between Stem and Progenitor Cells and the Microenvironment (R01)
To promote a thorough exploration and characterization of the bi-directional communication between multipotent cells and the three-dimensional local milieu or niche that they encounter in vivo under normal and compromised states, such as with aging or following injury, disease or drug exposure. Runs in parallel with R03.

Advances in Polycystic Kidney Disease (R01)
Basic and applied investigations to better understand the etiology and pathogenesis of PKD, in both its autosomal dominant and autosomal recessive forms. Runs in parallel with R21.

Characterization, Behavior and Plasticity of Pluripotent Stem Cells
Promote studies of stem cell biology and the regulation and control of stem cells in the nervous system. Research efforts on characteristics that distinguish between different types of stem cells and the cellular, molecular and genetic mechanisms that influence their lineage choices are particularly relevant, as are studies that explore the long-term fates of stem cell-derived populations in animal models. Runs in parallel with R21.

Posted 2/14/06
NIH Establishes Multiple PI Awards for the Support of TeamScience Projects
The National Institutes of Health (NIH) will begin to implement a Federal-wide policy to allow more than one Principal Investigator (PI) on individual research awards. This presents a new opportunity for investigators seeking support for projects or activities that clearly require a team science approaches and which do not fit the single-PI model. The multiple-PI model is intended to supplement, and not to replace, the traditional single PI model. 

NIH Adjusts Timeline for Electronic Application Submission of R0F1s
NIH has adjusted the implementation timeline for electronic application submission to provide an additional four months (one submission round) before the transition of the NIH traditional research grant (R01) mechanism and all subsequent mechanisms. 

Posted 9/29/05

Structural Analyses of the Ligand-Binding Properties of Taste and Smell Receptors (R01 & R21)
To foster innovative collaborative research to characterize the structural properties of taste and smell receptors. Additional emphasis is placed on the characterization of the interactions among odors, pheromones, and taste substances with their cognate receptors, and the identity of the critical ligand-receptor binding sites that determine sensitivity and selectivity.

Posted 9/20/05
NIA Aged Non-Human Primate Tissue Bank
The National Institute on Aging (NIA) announces a new resource for investigators in the field of aging research. The NIA Aged Non-human Primate Tissue Bank provides a repository of tissue from aged non-human primates (NHP) for use in research. Some tissue from middle-aged and young NHP will also be available soon. The primary focus will be on rhesus monkey tissue since this is the NHP model used most often for aging research. Other species will be included as they become available.

NINDS Cooperative Program in Translational Research ( U01, U54, U24)
To implement a program of cooperative agreements that will support milestone-driven projects focused on the identification and pre-clinical testing of new therapeutics. Program will facilitate the effective review and research administration of translational research projects and will accelerate the translation of discoveries in basic research to treatment in the clinic.

NINDS Mentored Research and Clinical Scientist Development Awards in Translational Research ( K01 and K08)
Career development award to enable investigators to build a program of translational research in neurological disorders under the guidance of an experienced mentor.

Posted 7/13/05
Small Grant Program for Conference Support (R13)
AHRQ seeks to support conferences that help to further its mission to improve the quality, safety, efficiency, and effectiveness of health care for all Americans. The types of conferences eligible for support include: 1) Research development - conferences where issues or problems in the delivery of health services are defined and a research agenda or strategy for studying them is developed; 2) Design and methodology - conferences where methodological and technical issues of major importance in the field of health services research are addressed or new designs and methodologies are developed; 3) Dissemination conferences - where research findings are summarized and communicated broadly to organizations and individuals that have the capability to use the information to improve the outcomes, quality, access to, and cost and utilization of health care services; and/or, 4) Research Training, Infrastructure and Career Development-conferences where research faculty and students are brought together with users of research to develop, share and disseminate research products, experiences, curricula, syllabi, approaches or core competencies required to train individuals from multi- and interdisciplinary backgrounds or prepare developing or emerging research institutions to conduct and translate research related to fostering improvements in health care delivery in the US. Applications due August 20, October 20, December 20, February 20, April 20, June 20 annually through June 20, 2008)

Posted 5/5/05
NIDDK Administrative Supplements for Human Embryonic Cell Line Research All requests for FY 2005 must be received by by July 1, 2005.

NIMH Policy Update for Career Awards (K-Series) The expiration date of many of the career award program announcements has been extended.

Interactions Between Stem and Progenitor Cells and the Microenvironment In Vivo NINDS, NIDA, NIDCD, NIA, NEI, NIBIB, NCI, and NIAAA invite applications for studies on the cellular and molecular signaling between the local environment within organisms and stem and progenitor cells that are either introduced as transplants or are normally resident within host tissues and organs. The objective of this initiative is to promote a thorough exploration and characterization of the bi-directional communication between multipotent cells and the three-dimensional local milieu or niche that they encounter in vivo under normal and compromised states, such as with aging or following injury, disease or drug exposure.

Posted 4/20/05
Tools for Zebrafish Research (R01)
Encourages investigator-initiated applications to exploit the power of the zebrafish as a vertebrate model for biomedical and behavior research. Applications are welcome proposing to develop new tools or genetic or genomic resources of high priority to the zebrafish community that will advance the detection and characterization of genes, pathways, and phenotypes of interest in development and aging, organ formation, behavior, sensory processing, physiological processes, and disease processes. Applications due September 19, 2005, 2006, 2007; letter of intent due one month prior.

NINDS Institutional Center Core Grants to Support Neuroscience Research (P30)
To support centralized resources and facilities shared by investigators with existing NINDS-funded research projects. Each Center will be composed of one or more research cores, each of which will enrich the effectiveness of ongoing research, and promote new research directions. There should be no overlap between the requested core facilities and other pre-existing core facilities Applicants may request up to $500,000 per year in direct costs. Application due on standard receipt dates; letter of intent due 30 days before.

Career Development Award to Promote Diversity in Neuroscience Research (K01)
Eligible organizations include domestic for-profit or non-profit organizations, public or private institutions such as universities, colleges, hospitals, and medical, dental, or nursing schools or other institutions of higher education involved in neurological research. Eligible principal investigators include individuals making the transition to an independent scientific career at the senior post-doctoral and junior faculty stages who come from groups shown to be underrepresented in neuroscience research.